MAPT and Alzheimer disease: To further confirm our findings as above, we conducted IF staining and found that felodipine-treated Tau Tg PS19 mice significantly decreased tau hyperphosphorylation at Ser202/Thr205 (AT8) and Thr212/Ser214 (AT100) in the cortex and hippocampus (Fig. 1H–K), suggesting that felodipine regulates tauopathy in early phase AD mice model.