Neurodevelopmental abnormalities marked by the presence of oversized organoids and irregular neural cell population composition135Reduced frequency of neuronal firing135Defective leptin signalling135Good correlation between expression defects in organoids and hypothalamus samples from PWS patients135Transplanted organoids in brain of adult mice exhibit higher number of infiltrated microglia with an activated morphology135. Here, LEP is linked to Prader-Willi syndrome.