This translational study employed matched pairs of tumor (T) and adjacent non-tumor (N) tissue from CRC patients to determine individual level differences as T/N ratios in telomere (TL, TA, TERT, TERC, TERRA) and proliferation (PCNA) parameters and extends previously published research on ESRP1 and ESRP2 [20]. Here, PCNA is linked to neoplasm.