IFNG and tuberculosis: On the other hand, the previous studies have shown that dcd homolog in M. marinum is specifically expressed in host granulomas but not in cultured macrophages [42], and the elevation of IFN-γ leads to an exacerbation of M. tuberculosis infection in mice [50] and tuberculosis reactivation in human [27], suggesting that IFNγ-dependent outgrowth of mycobacteria may be an unknown mechanism of tuberculosis activation and Dcd plays a central role in this mechanism.