The findings revealed a causal association between PAD and two inflammatory proteins: levels of Natural killer cell receptor 2B4 (OR, 1.219; 95% CI, 1.019-1.457; P=0.03) and Fractalkine (OR, 0.755; 95% CI, 0.591-0.965; P=0.025). The gene discussed is CD244; the disease is peripheral arterial disease.