pre-incubated RA-FLSs with TLR antagonists, followed by exposure to RA-NETs, and found that the ability to internalize MPO (a molecule present in NETs) was impaired, demonstrating that FLSs internalize NETs via the RAGE-TLR9 axis and the induced pro-inflammatory features of FLSs are dependent on NETs internalization (68). The gene discussed is TLR9; the disease is rheumatoid arthritis.