PRTN3 and rheumatoid arthritis: High levels of ACPA and RF inducing NETosis can be detected in the serum of RA patients (43) and promote the further production of autoantigens in the form of citrullinated protein, resulting in persistent inflammation and tissue damage; abnormal NETs may exacerbate the expression of citrullinated autoantigens and immune-stimulating molecules, thereby promoting the development of epitopes associated with RA pathogenesis.