FLSs internalize NETs containing arthrogenic peptides via the RAGE-TLR9 axis, promoting inflammatory response and cartilage damage (68)MMP plays an important role in cartilage degradation. There is a need to investigate the development of Antibody (Ab)-induced arthritis in MMP-2/MMP-9 mice (75)Elastase derived from NETs was found in the peripheral blood of RA patients to magnify cartilage injury and aggravate RA inflammation (76). This evidence concerns the gene MMP2 and arthritic joint disease.