Some reports are suggesting that WFS1 can also cause diabetes in an autosomal dominant mode (Bonnycastle et al., 2013), that WFS1 heterozygous variants can also cause WS (Gong et al., 2021; Morikawa et al., 2017), and that WFS1 compound heterozygous variants can also cause diabetes only (Li M. et al., 2020), complicating genotype-phenotype correlations and risking misdiagnosis. This evidence concerns the gene WFS1 and Werner syndrome.