Previous reports showed that HNF1B mutation contributed mainly to presentations of MODY5, including pancreatic hypoplasia, genital tract malformations, abnormal liver function, kidney dysfunction, learning disabilities, autism spectrum disorder, schizophrenia, müllerian abnormalities, and early-onset gout (Clissold RL et al., 2015; Bingham et al., 2024; Bockenhauer and Jaureguiberry, 2024; Clissold et al., 2024). The gene discussed is HNF1B; the disease is autism spectrum disorder.