HMGB1 and neoplasm: Detailed experimental results revealed that OPDEA-PDCA primarily induced pyroptosis in tumor cells by inhibiting PDHK1, increasing mitochondrial reactive oxygen species (mtROS) production, and activating cytochrome C. Notably, the pyroptosis triggered by OPDEA-PDCA was qualified as immunogenic cell death (ICD), confirmed through the release of immunogenic factors like IL-1β and high mbility group protein 1 (HMGB1), which fostered a pro-inflammatory tumor microenvironment.