Increased HSC70 mRNA expression was observed in SH-SY5Y cells treated with sAPPα (Masi et al., 2023).On the other hand, experiments have found that inhibiting HSC70 activity can reduce amyloid deposition and PHF-Tau formation in the CA1 region of AD model mice (Yang and Tohda, 2018). This evidence concerns the gene HSPA8 and Alzheimer disease.