HSPA8 and Alzheimer disease: HSPA8 encodes Heat Shock Cognate Protein 70 (HSC70), a molecular chaperone of the heat shock protein (HSP) family (Stricher et al., 2013).HSC70 recognizes substrate proteins in chaperone-mediated autophagy (CMA) (Liao et al., 2021), and the carboxyl-terminus of Hsc70 interacting protein (CHIP) connects to the UPS to target various proteins for degradation (Meimaridou et al., 2009).HSC70 has a complex relationship with AD pathology.