RELA and Parkinson disease: According to the target gene information from PubChem, in a Parkinson’s disease cell model, berberine inhibits the activation of the NF-κB pathway by modulating the LINC00943/miR-142-5p/KPNA4 axis, thereby reducing the nuclear translocation of the transcription factor p65 (RELA) (Li et al., 2021).