NFKB1 and Alzheimer disease: TCM exerts a synergistic effect in AD patients by targeting multiple pathways involved in the pathological progression of AD (Zhang Y. et al., 2015), including the ubiquitin-proteasome pathway, the autophagy-lysosome pathway, and the NF-κB pathway (Ding et al., 2022).TCM has been proven effective in the early prevention of AD and in enhancing brain activity in individuals with AD (Zhang et al., 2019).