According to the Chinese Integrated Clinical Management Guidelines for Precancerous Lesions of Gastric Cancer (Wang et al., 2022), common therapies for PLGC include eradicating Hp (positive cases) and short-term use of acid suppressants, mucosal protectors, etc., as well as using endoscopic surgical techniques combined with botanical drugs to treat high-grade dysplasia and early GC. Here, HP is linked to gastric cancer.