Stimulation of autophagy may prevent intracellular protein accumulation, such as the classical α-synuclein (α-syn), p-tau and Aβ and extracellular plaque deposits (Giannakopoulos et al., 2003; Ethell, 2010) in several models of AD and PD (Khandelwal et al., 2011; Lonskaya et al., 2013a,b, 2014). The gene discussed is MAPT; the disease is Alzheimer disease.