It has been previously shown that DDR1 is upregulated in postmortem AD and PD brains, and that lentiviral shRNA knockdown of DDR1 reduces the levels of α-syn, tau, and Aβ and prevents cell loss in vivo and in vitro (Hebron et al., 2013b; Fowler et al., 2019). This evidence concerns the gene DDR1 and Alzheimer disease.