Mutations to the SH3 domain of c-Abl are associated with unregulated cell growth and oncogenesis, and in fact c-Abl has been investigated as a contributing factor to chronic myelogenous leukemia (CML) (Bartram et al., 1983; Smith et al., 2003). Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.