IGFBP2 and Onset: Patients with long-term diabetes had a relatively lower IGFBP2 than those without diabetes (336.4 ± 205.3 ng/mL vs 442.6 ± 176.2, P = 0.0359), while patients with new-onset diabetes exhibited a significantly higher IGFBP2 (585.4 ± 317.2 ng/mL) than patients without diabetes (P = 0.0466).