The TG-rich lipoproteins through the TG hydrolysis process by lipoprotein lipase (LPL) contribute to low-grade inflammation of the arterial wall.26 Inflammation has a pivotal role in both arterial stiffening and atherosclerosis.27 In anin vitro study, C-reactive protein (CRP) decreased endothelial NO synthase (NOS) secretion and activity, resulting in “functional” arterial stiffening. The gene discussed is LPL; the disease is atherosclerosis.