Co-incubation experiments revealed that mesophilic granulocytes themselves can mediate the tumor-killing effect in a variety of ways, including stimulating stimulation of CD4+ and CD8+ maturation through the release of a variety of cytokines such as alerting, arginase-I, and MPO, or by increasing the influx of Ca2+ into the tumor73,.74 Here, CD8A is linked to neoplasm.