HOXD13 and neoplasm: sPD-1/Ce6, with the assistance of engineered nano-assisted sPD-1/Ce6, enables tumor cell-targeted delivery and localized release, which, on the one hand, induces cancer cell death under ultrasonication conditions by cavitation and acoustic wave effects, expanding the integrity and permeability of the vascular wall and the cellular membrane, in addition, driven by Ce6-induced SDT, sPD-1 increased the production of immune factors and the killing of NKs and CTLs, resulting in effective synergistic immunotherapy against HCCs192 (as shown in Table 2, 180,181,185,189,191,192).