Using the RasV12dlgRi model, tumor-secreted matrix metalloproteinase 1 (Mmp1) was found to alter the availability of Gbb, a ligand for TGFβ, in tumors and trigger TGFβ activation in adiposomes, leading to disruption of basement membrane (BM)/extracellular matrix (ECM) proteins at intercellular adhesion sites in adipocytes. The gene discussed is MMP1; the disease is neoplasm.