Liver metabolism is impaired in Walker 256 tumor cachexia and is more severe in the cachexia model in weaned rats15; administration of high doses of insulin increases p-Akt levels in the adipose tissue of rats with tumors, decreases p-HSL levels, and inhibits adiposity and weight loss in rats with tumors, demonstrating that activation of Akt is a potential strategy to prevent adiposity in cancer cachexia.34 The gene discussed is AKT1; the disease is cancer.