DDIT4 and cancer: In LLC-induced cancer cachexia, skeletal muscle Redd1 expression was increased, Akt and 4E-BP1 phosphorylation was unaffected in muscle from knockout Redd1 mice, mTORC1 activity was maintained, and dephosphorylation of muscle Foxo3a was inhibited, suggesting that knockout Redd1 prevents loss of body weight and lean tissue mass by regulating protein synthesis and degradation pathways, but not fat mass, but did not affect fat mass.72