Yki is a homolog of the human oncogene YAP1, which leads to excessive proliferation of intestinal tumor cells and causes systemic organ depletion, including muscle dysfunction, fat loss, hyperglycemia, and even death.95, 96, 97 Another model is RasV12scrib−/−, which can induce malignancy in Drosophila by knocking down the tumor suppressor scribble (scrib) in the background and expressing oncogenic Ras (referred to as RasV12). This evidence concerns the gene YAP1 and intestinal neoplasm.