Two cachexia biomarkers, activin A and GDF15, were significantly increased in mouse serum; protein hydrolysis was hyperactivated in muscle, muscle-specific E3 ligases Atrogin-1 and Murf-1 were significantly upregulated, and the cross-sectional area of muscle fibers was reduced; adipose tissue was significantly lost, uncoupling protein 1 (Ucp1) was upregulated and was accompanied by adenofibrosis. Here, UCP1 is linked to Cachexia.