NFKB1 and neoplasm: A study using the Yki3SA Drosophila tumor model further revealed that the inhibition of antimicrobial enzyme PGRP-SC2 activity in the gut of tumor-bearing Drosophila and an increase in the number of commensal bacteria led to abnormal activation of NF-κB in the kidney, causing uric acid, and circulatory disturbances.