CHDH and fragile X syndrome: In FXS research, the absence of FMRP protein is associated with significant changes in the expression of subunits of chromatin remodeling factors such as the Arid1 family, CHD family, and Smarca family (Korb et al., 2017; Richter and Zhao, 2021), which are closely related to neurodevelopment (Moffat et al., 2022; Wischhof et al., 2022; Liu et al., 2023; Loblein et al., 2023).