Knockdown of ALKBH5 enhanced the expression of mesenchymal markers, such as α-smooth muscle actin and snail, while overexpression of ALKBH5 increased the expression of the epithelial adhesion molecule E-cadherin and decreases snail expression, alleviating renal fibrosis (Ning et al., 2020), suggesting that ALKBH5 might play an important role in the EMT process. The gene discussed is ALKBH5; the disease is renal fibrosis.