Knockdown of ALKBH5 enhanced the expression of mesenchymal markers, such as α-smooth muscle actin and snail, while overexpression of ALKBH5 increased the expression of the epithelial adhesion molecule E-cadherin and decreases snail expression, alleviating renal fibrosis (Ning et al., 2020), suggesting that ALKBH5 might play an important role in the EMT process. This evidence concerns the gene SNAI1 and renal fibrosis.