ALKBH5 and Hepatic fibrosis: In vitro and in vivo models, including HSCs and clinical cases or CCl4-induced mice liver fibrosis, ALKBH5 triggered PTCH1 activation in an m6A-dependent manner, leading to hedgehog signaling inactivation, which inhibited the transformation of HSCs into myofibroblasts and ameliorated liver fibrosis (Yang et al., 2022).