In vitro and in vivo models, including HSCs and clinical cases or CCl4-induced mice liver fibrosis, ALKBH5 triggered PTCH1 activation in an m6A-dependent manner, leading to hedgehog signaling inactivation, which inhibited the transformation of HSCs into myofibroblasts and ameliorated liver fibrosis (Yang et al., 2022). This evidence concerns the gene PTCH1 and Hepatic fibrosis.