Of note, all eight tumors harboring either a missense or a frameshift TP53 mutation exhibited absent expression mutation-pattern p53 staining, which suggests that there was likely concurrent loss of heterozygosity in TP53. The single tumor that harbored both a frameshift and a nonsense (R210X) TP53 mutations exhibited diffuse expression p53 mutation pattern. Here, TP53 is linked to neoplasm.