investigated the association between HR defects and genomic patterns of LOH in two cohorts of epithelial ovarian tumors, finding a highly significant correlation between a HRD score defined as the number of LOH regions of intermediate size (> 15 Mb, but shorter than the length of the whole chromosome) and HR deficiency, measured by BRCA1/2 and RAD51C mutations (18). The gene discussed is BRCA1; the disease is ovarian epithelial tumor.