As a side note, we also confirmed strong and abundant expression of APP by glioblastoma tumor cells, similar to reports in several cancer types including melanoma metastases, where the expression of APP was a prerequisite for successful brain seeding.42,45 With an increasing armamentarium of melanoma-directed drugs and increasing patient survival, it will be interesting to study long-term effects on Abeta aggregation and spread in those patients. Here, APP is linked to glioblastoma.