Among samples with isolated pTau deposits (N = 41), 24 samples were screened for 3 and 4 repeat tau isoforms with 8 having both isoforms, consistent with ADNC, and 16 cases displaying 4 repeat tau only (Supplementary Figure S4A).25 Among the 16 cases, 9 showed pTau deposits in glial cells (N = 8) and grains (N = 1), indicative of another 4R tauopathy and were removed for further ADNC-related analyses. This evidence concerns the gene MAPT and tauopathy.