A comprehensive analysis of DNA methylation and transcriptomics in a substantial CNS-PNET cohort by Sturm et al. identified 4 distinct CNS tumor subtypes, each linked to recurrent genetic events and named accordingly.2 In the “2021 WHO Classification of Tumors of the Central Nervous System,” CNS NB-FOXR2 emerged as a novel malignant subtype. The gene discussed is FOXR2; the disease is central nervous system cancer.