Despite individual differences in expression levels, COL4A2 expression was significantly greater in THCA tumor tissues than in paired adjacent normal tissues (Fig. 2E), and patients with higher COL4A2 expression in THCA tissues had lower overall survival than patients with lower transcript levels (median survival time 102.4 vs. 139.4, p = 0.041; Fig. 2F). This evidence concerns the gene COL4A2 and neoplasm.