These results indicate that acetate facilitates acetate uptake, glycolysis, and NSCLC cell proliferation, and PD‐L1‐dependent inhibition of CD8+ T‐cell activation dependent on the acetate‐MCT1‐ACSS2‐DLAT‐USP10‐c‐Myc axis (Figure 1). Here, MYC is linked to non-small cell lung carcinoma.