Adding clindamycin with LyeTxI-b showed an even more significant reduction in inflammatory cytokines, indicating a possible synergistic relationship between AMPs and antibiotics traditionally used in treating septic arthritis [73]. Elevated matrix metalloproteinases (MMPs) in septic arthritis often exacerbate joint destruction through extracellular matrix degradation, leading to irreversible cartilage damage [74,75]. This evidence concerns the gene ADSL and bacterial arthritis.