TP53 and neoplasm: The results show that HG tumors had significant hypermethylation and hypomethylation of the promoter FGFR3 (p < 0.05) and TP53 (p < 0.05), and the evaluation and co-relation of methylation-induced gene silencing or induction shows that the level of FGFR3 gene was significantly downregulated in HG tumor (p < 0.001) compared to LG tumors.