FGFR3 and neoplasm: Mutations, gene amplifications, and epigenetic regulation of FGFR3 lead to the activation of downstream pathways such as RAS-MAPK and PI3K-AKT and associated genes to promote uncontrolled cell growth leading to tumor formation [13]. However, p53 regulates the cell cycle, DNA repair, apoptosis, autophagy, and metabolism and maintains genome stability [14,15].