RASSF1 and neoplasm: The Cox proportional hazard regression analysis based on the FGFR3 and TP53 promoter methylation status indicated that FGFR3 hypermethylation was significantly associated with RFS (HR = 3.47; p = 0.045) and PFS (HR =3.85; p = 0.022). A multivariate result shows that RASSF1A and DAPK methylation, tumor grade, and stage were significantly associated with disease progression (p = 0.04) [28].