AC, anticoagulation; AST, aspartate aminotransferase; ALT, alanine aminotransferase; DOAC, direct oral anticoagulant; TIPS, transjugular intrahepatic portosystemic shunt; JAK2, Janus kinase 2; PVT, portal vein thrombosis. The gene discussed is JAK2; the disease is Portal vein thrombosis.