SERPINC1 and malaria: Early studies of the mechanisms involved in the activation of the coagulation cascade in severefalciparum malaria in Thai adults, many of whom had multiple vital organ dysfunction, suggested activation of the intrinsic pathway of the clotting cascade and complement system including reduction in the concentration of plasma antithrombin III (AT III) concentrations, elevation in thrombin-AT III (TAT) complexes50,51, and reductions in factor XII and pre-kallikrein activities.