Increased levels of proteins participating in apoptotic signaling (TMBIM1), innate (TMBIM1, IGKV2-29, IGHV3-23, and DEFA6), humoral immune response (MRC2, IGKV2-29, and IGHV3-23), and cellular response to lipopolysaccharides (IGHV3-23 and DEFA6) represent the enhanced mitochondrial pathway of apoptosis which might contribute toward AKI to CKD progression. This evidence concerns the gene DEFA6 and chronic kidney disease.