TGF-β-inducible protein IG-H3, the second most abundant protein in corneal stroma, is encoded by the βIG-H3 gene, which was first identified by differential screening of cDNA libraries extracted from A549 human lung adenocarcinoma cells treated with TGF-β and was located on human chromosome 5q31. Here, TGFBI is linked to lung adenocarcinoma.