COL8A2 and Fuchs endothelial corneal dystrophy: α2 chain of type VIII collagen is encoded by the COL8A2 gene, defect of this gene is associated with Fuch’s endothelial corneal dystrophy and posterior polymorphic corneal dystrophy type 2, and its related pathways include collagen chain trimerization and integrin pathway, with GO annotations related to this gene include ECM structural components and protein-macromolecular bridging subunit activity.