ECM not only serve as a solid support for cells, but also act as a reservoir for a variety of essential cytokines and growth factors (12), such as vascular endothelial growth factor (VEGF), transforming growth factor (TGF) and protease (13, 14), thus providing a library of bioactive molecules that contribute to tumor cell metastasis and angiogenesis. The gene discussed is VEGFA; the disease is neoplasm.