For instance, TNF-α facilitates the proliferation of keratinocytes in psoriasis, enhances the uptake of low-density lipoprotein in endothelial cells leading to the deposition of blood vessel walls in cardiovascular disease, and concurrently disrupts insulin metabolism, a factor closely associated with the development of non-alcoholic fatty liver disease (39–41). This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.