As expected, this GCSR is positively related to Spielberger’s State Trait Anxiety Inventory – Trait scale (STAI-T; Spielberger et al., 1983) and is reduced by single doses of selective drugs for anxiety, that is, buspirone, triazolam or pregabalin (McNaughton et al., 2013; Shadli et al., 2015), which act as a receptor partial agonist (5-HT1A), a Positive Allosteric Modulator (GABA-A receptor, benzodiazepine site), and a voltage-gated calcium channel blocker, respectively. This evidence concerns the gene HTR1A and Anxiety.