Plasma MMP-8 was significantly elevated in confirmed TB compared to no TB (median, 23 712 pg/mL [IQR, 7688–47 571 pg/mL] vs 10 602 pg/mL [IQR, 2019–32 205 pg/mL]; P = .003; Figure 1A and Supplementary Table 3), as was plasma Col4α1 (Figure 1B). The gene discussed is MMP8; the disease is tuberculosis.