These modifiable CVD risk factors have been shown to interact with age, sex, and apolipoprotein E(APOE) ε4 genotype, potentially influencing susceptibility to AD via actions on glial cells, changes in blood–brain barrier structure/function, and decreased perivascular clearance of Aβ peptides in animal models.7, 9, 10, 11. Here, APOE is linked to Alzheimer disease.