We next sought to gauge the relationship between specific MRI markers of CVD neuropathology and Aβ‐PET positivity in the overall cohort using a model that was adjusted by accessible measures of vascular risk (age, sex, APOE ε4), cognitive impairment (MoCA), and AD‐related atrophy (MTL volume [MTLv]) (Table 2). This evidence concerns the gene APOE and Alzheimer disease.