RCAN3 and papillary renal cell carcinoma: Additionally, RCAN3 expression in paired normal and tumor tissues from TCGA database was consistently upregulated in several cancers, such as BLCA, BRCA, CHOL, COAD, ESCA, LIHC, LUAD, LUSC, and STAD; in contrast, it was downregulated in kidney chromophobe (KICH), KIRC, and kidney renal papillary cell carcinoma (KIRP; Figure 1B).