PBRM1 and cancer: After adjusting for cancer types and filtering out MSI-High samples, the POL&PBRM1 group had the highest signature scores in all response signatures (GEP: FDR < 0.001, IFG: FDR < 0.001, TLS: FDR = 0.088, TIS: FDR < 0.001, ICR: FDR < 0.001, CTL: FDR < 0.001) (Supplementary Fig. 4a, Supplementary Table 3).