In the same manner, compared to the responsiveness of stem-like and terminally differentiated CD8 T-cell subsets isolated from tumor-bearing mice to PD-1 blockade in vivo, while the population of the terminally differentiated CD8 T-cell subset was not altered, stem-like CD8 T cells largely proliferated and were converted into terminally differentiated CD8 T cells20. This evidence concerns the gene CD8A and neoplasm.