AREG and neoplasm: The CMTM6 targets can be divided into different groups: (1) mitogens such as PDGF-BB, Amphiregulin, and TGFα; (2) cytokines/chemokines that are related to inflammation, such as IL-1α, IL-1β, IL6, IL11, CD14, CD160, Chemerin, Chitinase-3-like protein 1 (CHI3L1), Flt-3 ligands, G-CSF, M-GSF, ICAM-1, CD62E, CD62P, and VCAM1; (3) factors that are involved in the immunosuppressive tumor microenvironment, such as IL6, IL10, TNFα, CCL17, and IL15; and (4) factors that control endothelial cell survival and angiogenesis, such as CXCL12, angiopoinetin-1, GAS6, and MMP2 (Supplementary Fig. 3).