EMD and Familial prostate cancer: Most importantly, greater numbers of Emerin-rich structures were correlated with higher Gleason scores (a prostate cancer grading system), the presence of metastasis after radical prostatectomy and poorer patient prognosis (expressed as time to biochemical recurrence, i.e., time to an increase in the prostate-specific antigen (PSA) level after radical prostatectomy) after radical prostatectomy ( ≥ 75th percentile vs. <75th percentile: HR = 3.13, 95% CI: 1.64–5.98, Cox p-value = 0.0006; Fig. 1c).