Based on the data from GEPIA and TCGA, we found that fibronectin 1 (FN1), laminin subunit beta 3 (LAMB3), integrin subunit alpha 3 (ITGA3), syndecan-4 (SDC4), and IL1 receptor-associated protein (IL1RAP) were significantly overexpressed in thyroid cancer tissues compared with normal thyroid tissues (P < 0.01) (Fig. 9). The gene discussed is SDC4; the disease is thyroid cancer.