LINC02454 and thyroid gland carcinoma: Furthermore, Cao et al. demonstrated that upregulation of LINC02454 cis-regulated HMGA2 expression by facilitating CREB1 phosphorylation and nuclear translocation, and HMGA2 promoted LINC02454 expression by binding its promoter, thereby accelerating thyroid carcinoma colony formation, migration, invasion, and EMT [10].