Meanwhile, sPD-L1 levels could also be used as a risk biomarker for the occurrence of cancer metastasis in patients with CRC, [16, 124] upper tract urothelial carcinoma, [103] STS, [112] NPC, [88] and ccRCC [18]. This evidence concerns the gene SPDL1 and renal pelvis/ureter urothelial carcinoma.