DNMT1 and hematologic disorder: Results from early phase studies, notably those employing pulrodemstat for solid tumors and non-Hodgkin lymphoma, show significant anti-neoplastic effects, particularly in neuroendocrine tumors.579 Several non-histone proteins, including as DNMT1, are impacted by LSD1 in addition to histones.580 LSD1-mediated demethylation of DNMT1 is critical for its stabilization and the maintenance of global DNA methylation patterns.581 LSD1 inhibitors have the potential to be used in combination therapy for hematological malignancies.