P63 is upregulated during MET in a variety of cancer types and is essential for the maintenance of epithelial stem cells.262 P63 promotes the reactivation of epithelial genes like E-cadherin and cytokeratins, while suppressing mesenchymal genes like Vimentin and fibronectin.263 Twist and Snail have also been implicated in the regulation of MET and the colonization of tumor cells. This evidence concerns the gene TWIST1 and neoplasm.