It has also been demonstrated to play a role in the growth and metastasis of cancer cells.421 GCN5 is recruited to the Runx2 promoter to sustain H3K27ac levels, which leads to the upregulation of Runx2 and promotes lung metastasis in osteosarcoma.422 The biological function of HDACs in cancer is well-established. This evidence concerns the gene RUNX2 and osteosarcoma.