TGFB1 and cancer: For instance, it is known that the TGF-β pathway induces EMT in different forms of cancer by increasing the expression of associated transcription factors that inhibit E-cadherin.218,219 The Notch and Wnt pathways have also correlated with EMT and cell-cell junction disassembly in different cancer types.114,220,221 In conclusion, the disassembly of cell-cell junctions is a complex process that entails the dysregulation of multiple signaling pathways and transcriptional networks.