VIM and cancer: P63 is upregulated during MET in a variety of cancer types and is essential for the maintenance of epithelial stem cells.262 P63 promotes the reactivation of epithelial genes like E-cadherin and cytokeratins, while suppressing mesenchymal genes like Vimentin and fibronectin.263 Twist and Snail have also been implicated in the regulation of MET and the colonization of tumor cells.