CCNE1 and gastric cancer: Like with PDGFRA and FGF4, this results in oncogene activation and ectopic enhancer-promoter crosstalk.404,405 An explanation for the observed correlation between increased CCNE1 expression in gastric cancer primary tumors and CCNE1 rearrangement in response to changed TAD borders and interactions has been found.406 Because the promoter-enhancer looping dynamics are dysregulated, this rearrangement promotes oncogenicity.