Twist is upregulated during EMT and downregulated during MET.264 Twist improves the mesenchymal phenotype of tumor cells by suppressing E-cadherin expression and increasing N-cadherin and fibronectin expression.265 Snail, on the other hand, promotes EMT and invasion by inhibiting E-cadherin expression, but its role in MET and colonization is less clear. This evidence concerns the gene CDH1 and neoplasm.