The advancement of cancer has been linked to abnormal LSD1 amplification and activity.577 LSD1’s role in transcriptional repression involves removing methylation from H3K4me1/2, a marker of gene activation.578 Preclinical evidence of differentiation and growth attenuation has prompted the evaluation of LSD1 inhibitors, including pulrodemstat (CC-90011), iadademstat, seclidemstat, and GSK2879552, in a number of clinical trials. This evidence concerns the gene KDM1A and cancer.