CTC detection technologies are dependent on a number of melanoma cell adhesion molecules, which are highly specific molecular markers for melanoma and include HMW-MAA,62,64 MART-1,65,66 CD146,67,68 and MAGE A.66,67,69–71 Melanoma is a kind of skin cancer that starts in melanocytes. The gene discussed is MCAM; the disease is melanoma.