On the other hand, SLC27A5 (also known as FATP5), which serves as a suppressor in sorafenib-resistant hepatocellular carcinoma cells, markedly promotes sorafenib-induced ferroptosis by upregulating expression of glutathione reductase in an NRF2-dependent manner, disrupting the balance of GSH homeostasis [92]. The gene discussed is SLC27A5; the disease is hepatocellular carcinoma.