SLC3A2 deficiency promotes ferroptosis by upregulating the expression of the mTOR and p70S6K in laryngeal carcinoma [78], whereas targeting of the SLC3A2 subunit of system Xc− is essential for N6-methyladenosine reader YTHDC2 (YT521-B homolog 2) to function as an endogenous ferroptosis inducer in lung adenocarcinoma [79]. The gene discussed is SLC3A2; the disease is laryngeal carcinoma.