RNF122 and neoplasm: Additionally, depending on the CCK‐8, colony formation, Transwell migration/invasion, and in vivo animal experiments, WP1066 led to a significant reverse of the RNF122 effect on enhancing LN‐229 and A‐172 cell proliferation, migration, and invasion (Figures 5B,C and 6A), which was parallel to the in vitro study which verified that WP1066 treatment significantly decreased tumor growth in mice with GBM intracranial orthotopic transplantation more than in the respective cohorts.