Besides, c‐Myc silencing attenuated the promoting impacts of RNF122 overexpression on LN‐229 and A‐172 cell proliferation (Figure 8A,B), migration, and invasion (Figure 8C), which was parallel to the in vitro study, where c‐Myc silencing attenuated the promoting influences of RNF122 overexpression on LN‐229 and A‐172 cell growth in mice with GBM intracranial orthotopic transplantation tumor model more than in the corresponding cohorts. Here, RNF122 is linked to glioblastoma.