This was demonstrated by the results that overexpression of GLT‐1 in hippocampal astrocytes or inhibition of glutamatergic neuron excitability using chemogenetic means can effectively prevent or alleviate this hippocampus‐dependent cognitive impairment induced by hyperexcitability in T2DM mice suffering anesthesia/surgery. The gene discussed is SLC1A2; the disease is Cognitive impairment.