The current data also indicated that hippocampal glutamatergic neurons were activated after anesthesia/surgery, and reduced GLT‐1 expression in hippocampal astrocytes of type 2 diabetic mice significantly amplified the increase in glutamatergic neuron excitability induced by anesthesia/surgery and triggered POCD in early T2DM adult mice. Here, SLC1A2 is linked to type 2 diabetes mellitus.