TP53 and B-cell chronic lymphocytic leukemia: An experiment conducted using cell lines derived from patients with B‐cell chronic lymphocytic leukemia (B‐CLL) revealed that miR‐15a and miR‐16‐1 are deregulated and directly target the p53 protein in a positive feedback loop, wherein these miRNAs are also regulated by direct binding of p53 [57].