MYBPC3 is a sarcomere component of heart muscle and mutations in the gene are associated with hypertrophic cardiomyopathy [102], while SPI1 is a transcription factor with an ETS-domain and its expression in cardiac tissue was found to increase during myocardial infarction as a result of reduced DNA methylation, in mice [103]. Here, SPI1 is linked to hypertrophic cardiomyopathy.