In this study, more individuals in GLP1-RAs group regressed from prediabetes to normoglycemia than subjects in the placebo group (OR = 4.56, 95% CI 3.58–5.80); fewer individuals in GLP1-RAs group were diagnosed with T2DM than those in the placebo group (OR = 0.31, 95% CI 0.12–0.81). This evidence concerns the gene GCG and prediabetes syndrome.