Recent data about the effects of semaglutide (and liraglutide) on obesity induced by diet in rodents suggest that the impact of systemically administered GLP1-RA on appetite, satiety, calorie intake, and body weight involves the arcuate nucleus in the hypothalamus, the area postrema, and the nucleus tractus solitarius.[51, 52] Interestingly, GLP1-RA can impact food choices by promoting the selection of healthier, less energy-dense foods in human studies [53, 54]. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.