In only one pair of tumors, extensive genomic differences in the recurrent tumor that were not present in the primary tumor, were found such as CDKN1B (rs146973564, c.C365T, p.P122L) and MLH1 (rs1799977, c.A655G, p.I219V) among others (Fig. 1D–F). Here, CDKN1B is linked to neoplasm.