GNAS and neoplasm: The somatotroph PitNET showed a high degree of genetic heterogeneity between the primary and the recurrent tumors with extensive genomic differences in more than 40% of the SNV profiles; SNV were found in AIP (rs641081, c.C682A, p.Q228K), in both, the primary and the recurrent lesion (Fig. 2D–F), whereas the SNV found in GNAS (rs11554273, c.C601T, p.R201C) and GPR101 (rs1190736, c.G370T, p.V124L) were present only in the recurrent tumor.