MAGEL2, where 37% NB tumours displayed LOM and 28% Intermediate LOM, belongs to a highly conserved group of proteins (MAGE-The Melanoma Antigen Gene), which are reported to be deregulated in multiple cancers [46–48] including central nervous system tumours medulloblastoma [49] and glioblastoma [50]. This evidence concerns the gene MAGEL2 and neoplasm.