MAGEL2 and neoplasm: Methylation alterations (GOM or LOM) at NNAT/BLCAP (BH adjusted P = 2.0e-08), RB1 (BH adjusted P = 2.4e-14) and MAGEL2 (BH adjusted P = 5.3e-08) showed an enrichment for the methylation subclass Mycn Type. Interestingly, most of the tumours that retained their methylation profile (No change group) at these DMRs were classified as Tmm negative (76% of cases with no change at NNAT/BLCAP, 55% at RB and 53% at MAGEL2) (Fig. 3E).